{"id":1425,"date":"2012-04-03T06:17:53","date_gmt":"2012-04-03T06:17:53","guid":{"rendered":"http:\/\/impulse-dynamics-multisite.flywheelsites.com\/ous\/int\/?p=1425"},"modified":"2012-04-03T06:17:53","modified_gmt":"2012-04-03T06:17:53","slug":"new-article-published-in-the-int-j-of-cardiology-compares-lv-reverse-remodeling-induced-by-ccm-and-crt","status":"publish","type":"news","link":"https:\/\/impulse-dynamics.com\/global\/news\/new-article-published-in-the-int-j-of-cardiology-compares-lv-reverse-remodeling-induced-by-ccm-and-crt\/","title":{"rendered":"New article published in the Int. J. of Cardiology compares LV reverse remodeling induced by CCM and CRT"},"content":{"rendered":"<p><strong>ABSTRACT<\/strong><\/p>\n<p><em>Background:<\/em> Cardiac contractility modulation (CCM) is a new device-based therapy for advanced systolic heart failure with normal QRS duration and therefore not suitable for cardiac resynchronization therapy (CRT). Left ventricular (LV) reverse remodeling was reported in patients treated with CCM or CRT, however, the extent of response was not compared.<\/p>\n<p><em>Methods:<\/em> This observational study consisted of three groups of patients with symptomatic heart failure and LV ejection fraction\u00a0&lt; 35% despite optimal medical therapy. Group 1 included those received CCM with a QRS duration\u00a0&lt; 120 ms (n = 33), Group 2 included those received CRT with a QRS duration of 120 \u2013150 ms (n = 43), and Group 3 included those received CRT with a QRS duration &gt; 150 ms (n = 56). LV end-systolic volume (LVESV) was measured at baseline and 3 months later.<\/p>\n<p><em>Results:<\/em> Age, gender, etiology of heart failure and baseline ejection fraction were comparable. A significant LV reverse remodeling was observed in each group. The degree of LVESV reduction was similar between Group 1 and Group 2 (? 11.3 \u00b1 11.8 vs. ? 13.6 \u00b1 18.3%, p = 0.833), however, it was greater in Group 3 (? 25.0 \u00b1 18.0%, both p b 0.01). By using the reduction ? 15%, the responder rate was not different between Group 1 (39%) and Group 2 (42%), but significantly higher in Group 3 (68%) (? 2 =9.514, p =0.009).<\/p>\n<p><em>Conclusion:<\/em> CCM exhibited a similar LV reverse remodeling response to CRT for patients with a mildly prolonged QRS, though the effect was less strong when compared to CRT for patients with a very wide QRS<\/p>\n<p><a href=\"https:\/\/impulse-dynamics.com\/ous\/int\/wp-content\/uploads\/sites\/2\/sites\/2\/2012\/04\/CMYu-CRT-vs-CCM-Reverse-Remodeling.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Download the full article<\/a><\/p>\n","protected":false},"featured_media":0,"template":"","class_list":["post-1425","news","type-news","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>New article published in the Int. J. of Cardiology compares LV reverse remodeling induced by CCM and CRT - Global - Impulse Dynamics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/impulse-dynamics.com\/global\/news\/new-article-published-in-the-int-j-of-cardiology-compares-lv-reverse-remodeling-induced-by-ccm-and-crt\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"New article published in the Int. J. of Cardiology compares LV reverse remodeling induced by CCM and CRT - Global - Impulse Dynamics\" \/>\n<meta property=\"og:description\" content=\"ABSTRACT Background: Cardiac contractility modulation (CCM) is a new device-based therapy for advanced systolic heart failure with normal QRS duration and therefore not suitable for cardiac resynchronization therapy (CRT). Left ventricular (LV) reverse remodeling was reported in patients treated with CCM or CRT, however, the extent of response was not compared. 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Methods: This observational study [&hellip;]","og_url":"https:\/\/impulse-dynamics.com\/global\/news\/new-article-published-in-the-int-j-of-cardiology-compares-lv-reverse-remodeling-induced-by-ccm-and-crt\/","og_site_name":"Global - Impulse Dynamics","twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/impulse-dynamics.com\/global\/news\/new-article-published-in-the-int-j-of-cardiology-compares-lv-reverse-remodeling-induced-by-ccm-and-crt\/","url":"https:\/\/impulse-dynamics.com\/global\/news\/new-article-published-in-the-int-j-of-cardiology-compares-lv-reverse-remodeling-induced-by-ccm-and-crt\/","name":"New article published in the Int. 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